UCT Protein Intelligence v4

ANALYTICAL PROTEIN PHYSICS · ZERO TRAINING DATA · STRUCTURAL LAW · 15 MODULES
ΔG = ⅔ − ⅓·nNP + 0.389·nHB + 3·|Qeff|  |  R²=0.962  |  Novgorodtsev 2026

ΔG Structural Profile (with corrections)

L1+L2

Folding Nuclei & Backbone Map

L2
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Second-Order Corrections Applied

NEW
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Certificate

L1

Secondary Structure

L2
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Contact Map + Disulfides

L2+SS

ΔΔG Mutation Heatmap (with corrections)

L1+L2
Hover for details · Includes ring strain & backbone corrections

Disulfide Bond Analysis

SECOND ORDER
Cys residues detected. Potential S-S bonds scored by sequence separation, predicted proximity, and conservation pattern.
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Disulfide Impact on Stability

L2
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Post-Translational Modifications

SECOND ORDER
Click a residue position, then select a PTM to apply. ΔΔG computed from coordinate shift in (n_NP, n_HB, Q_eff) space.
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PTM Registry — Hydrophobic + Steric Components

L2

Membrane Topology (with backbone correction)

L2+BB
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Aggregation-Prone Regions (APR)

ANALYTICAL
Exposed hydrophobic patches → aggregation risk

Thermostability — ΔG(T) Curve

ANALYTICAL
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pH Stability Profile

L2
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Protease Susceptibility Map

ANALYTICAL
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Multimer Interface Analysis

MODULE 6
Enter Chain B and run analysis

Immunogenicity Screen (MHC-II 9-mer)

ANALYTICAL
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Reverse Translation + Codon Optimization

EXPRESSION
Run analysis first...
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Run analysis first...
UCT Protein Intelligence v4 · 15-Module Analytical Protein Physics · Aleksei Novgorodtsev · ORCID 0009-0009-2407-7049
ΔG = ⅔ − ⅓·n_NP + 0.389·n_HB + 3·|Q_eff| · R² = 0.962 · Zero training data · All coefficients from structural law
doi:10.5281/zenodo.19978109 · UCT v22 — One Fixed Point, Two Projections, All Architecture